APP C-Terminal Fragments Stifle Calcium Flow from ER to Lysosomes
Amyloid precursor protein CTFs accumulate in lysosomes adjacent to endoplasmic reticulum. This disrupts calcium flow between the organelles.
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Amyloid precursor protein CTFs accumulate in lysosomes adjacent to endoplasmic reticulum. This disrupts calcium flow between the organelles.
Scientists find the senescent subtype has a distinct protein signature, but little change in gene expression, causing it to be overlooked in transcriptomic studies.
Lysosomes deliver a plethora of mRNA transcripts, including those encoding ribosomal subunits and mitochondrial proteins, to axonal terminals for translation.
In a small Phase 2 trial, the GLP-1 analogue lixisenatide stabilized motor abilities over one year in people with early PD.